Methylene ATP analogs as modulators of extracellular ATP metabolism and accumulation

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Methylene ATP analogs as modulators of extracellular ATP metabolism and accumulation.

1 Transient accumulation of extracellular ATP reflects both release of ATP from intracellular stores and altered rates of ATP metabolism by ecto-enzymes. Ecto-nucleoside triphosphate diphosphohydrolases (eNTPDases) and ecto-nucleotide pyrophosphatases (eNPPs) degrade ATP, while ecto-nucleotide diphosphokinases (eNDPKs) synthesize ATP from ambient ADP. 2 Although the methylene ATP analogs betaga...

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ژورنال

عنوان ژورنال: British Journal of Pharmacology

سال: 2004

ISSN: 0007-1188

DOI: 10.1038/sj.bjp.0705865